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About Cologuard

Did you know? 

  • Colon cancer is the 2nd leading cause of cancer-related deaths
  • When caught early, it's treatable in 90% of people

Cologuard is an easy, noninvasive colon cancer screening test you can use at home. It's the only FDA-approved test based on stool DNA science and finds 92% of colon cancers. Plus, it's covered by Medicare and most major insurers.

If you've been putting off screening, and you're 45 years of age or older at average risk for colon cancer, ask your healthcare provider today if this noninvasive option is right for you. 

To learn more, visit CologuardTest.com

*Cologuard performance in adults 45-49 is estimated based on a large clinical study of patients 50 and older. 

About Cologuard

Indications for Use 

Cologuard is intended to screen adults 45 years of age or older who are at average risk for colorectal cancer by detecting certain DNA markers and blood in the stool. Cologuard is not a replacement for surveillance colonoscopy in high risk individuals for diagnostic colonoscopy. 

Important Risk Information

Cologuard should not be used if you:

  • Have a history of colorectal cancer, adenomas or other related cancers
  • Had a positive result from another colorectal cancer screening test within the last 6 months
  • Have a condition that places you at high risk for colorectal cancer, including Inflammatory Bowel Disease (IBD) or certain heriditary syndromes or a family history of colorectal cancer
  • Talk to to your healthcare provider if any of these situations apply to you

The Cologuard test result should be interpreted with caution. A positive test does not confirm the prescence of cancer. Patients with a positive test should be referred for diagnostic colonoscopy. 

A negative test result does not confirm the absence of cancer. Patients with a negative test result should discuss with their healthcare provider when they need to be tested again. 

False positives and false negatives can occur. In a clinical study, 13% of people without cancer received a positive result (false positive) and 8% of people with cancer received a negative test result (false negative). It is important to talk to your doctor about your test results. 

Cologuard performance in adults ages 45-49 is esitmated based on a large clincial study of patients 50 and older. 

Do not provide a sample for Cologuard if you have diarrhea or have blood in your urine or stool. 

The risks related to using thd Cologuard Collection Kit are low, with no serious adverse events reported among people in a clinical trial. You should be careful when opening and closing the lids to avoid the risk of hand strain. 

Please read the Instructions for Use and talk to your healthcare provider to see if Cologuard is right for you. The product is available by prescription only. 

Cologuard colorectal cancer screening test in a registered trademark of Exact Sciences Corporation. 

For complete information on Cologuard, please click here. 


1. American Cancer Society. Key statistics for colorectal cancer. www.cancer.org/cancer/colon-rectal-cancer/about/key-statistics.html. Last revised January 2019. Accessed October 23, 2019.

2. National Cancer Institute. SEER Cancer stat facts: colorectal cancer. www.seer.cancer.gov/statfacts/html/colorectal.html. Accessed October 23, 2019. 

3. Imperiale TF, Ransohoff DF, Itzkowitz SH, et al. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med. 2014;370(14):1287-1297.